CaSToRC, the HPC National Competence Centre,
invites you to the SimEA Online Seminar Series

About the SimEA project Seminar Series

The SimEA project Seminar Series aims at promoting and disseminating scientific knowledge, focusing on Computational Science and Engineering, by featuring prominent researchers from around the world presenting their views and addressing key questions. 

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 810660.

Abstract

Multi-scale structural assessment of biological tissues and organs is essential to gain insight into their structure-function relationship [1,2]. For example, the human placenta is a highly complex and unique multi-functional organ. It is a life-support system that not only nourishes a growing fetus, but also determines her or his life-long health. The placental primary exchange units, terminal villi, host dense networks of fetal capillaries and are interfaced with maternal blood, percolating a disordered porous medium. While placental transport at the micro-scale can be described by established models, systematically upscaling the transport and quantifying the associated uncertainty at the organ-level remain open challenges [1]. This talk will summarise recent progress in advanced 3D microscopy and its assimilation into mathematical models that predict placental function [2]. The models reveal a surprising role of microstructure in the upscaled predictions and demonstrate certain universality of reduced-order approximations for a wide class of solutes and transport regimes [3]. The developed approaches could also be useful for multi-scale modelling of solute exchange in other complex microvascular systems.

References

1. Jensen O.E. & Chernyavsky I.L. (2019) Annu Rev Fluid Mech 51:25 (doi.org/10.1146/annurev-fluid-010518-040219).
2. Tun W.M., et al. (2020) bioRxiv 2020.12.07.411462 (doi.org/10.1101/2020.12.07.411462).
3. Erlich A., et al. (2019) Sci Adv 5:eaav6326 (doi.org/10.1126/sciadv.aav6326).

About the Speaker

 Dr Igor Chernyavsky is the University of Manchester's Presidential Academic Fellow in Applied Mathematics. Igor’s research primarily focuses on the mechanics and transport processes in complex biological systems, such as the human placenta. He develops image-based multiscale methods for solving fundamental problems of mathematical physiology within hand's reach of clinical applications.

Download the Spring 2021 Online EuroCC & SimEA Seminar Series Programme here.

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